Diabetes Genetic
Testing
Why Kingdom Health Laboratory?
There are several benefits
Overall, it can mean less invasive and/or more effective treatment. A diagnosis of HNF4A- or HNF1A-diabetes (also called MODY1 and MODY3) indicates that the most effective treatment, especially early in the disease course, is likely to be low dose sulfonylurea pills. This treatment promotes insulin secretion rather than the insulin injections used to treat type 1, or the metformin (which promotes insulin sensitivity) usually tried first for type 2 diabetes.
A diagnosis of GCK-diabetes
(also called MODY2), which causes stable mild hyperglycemia, usually indicates that no treatment is needed because this mild hyperglycemia is generally not associated with the complications seen in other types of diabetes.
A diagnosis of potassium channel diabetes, caused by mutations in KCNJ11 or ABCC8, usually allows patients to transition from insulin injections to high dose sulfonylurea pills, often with improvements in glucose control.
A positive result for any form of monogenic diabetes makes it easier to correctly diagnose and accurately predict risk of diabetes in relatives.
Who is the test for?
Patients with a personal and/or family history suggestive of monogenic diabetes and obesity related disorders. These conditions may occur independently or as clinical features of a genetic syndrome.
What are the potential benefits for my patient?
Patients identified with a disease-causing change (a pathogenic or likely pathogenic variant) in a gene on this panel may benefit from increased surveillance, targeted and personalized management, and preventative steps to better manage their risk.
Who would be the best candidates
for diabetes genetic testing?
- Diabetes diagnosed in infancy;
- Apparent type 2 diabetes diagnosed by age 30 and/or not having typical risk factors;
- Type 1 diabetes without diabetes auto-antibodies, especially in a parent and child;
- Lean women who develop gestational diabetes with high fasting glucose;
- Diabetes accompanied by other non-pancreatic features suggestive of a syndrome;
The Staggering Costs of Diabetes
for the United States
Kingdom Health Laboratory
PH 469.995.7877 · KingdomHealthlab.com